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Several pairs of measures are used to determine how well a diagnostic test performs relative to the known proportions of individuals with and without the disorder. Diagnostic accuracy is critical in the evaluation of medical diagnostic tests (Leeflang et al. 2013b).  Methods to summarize the results of diagnostic studies are available for both binary and continuous data (Lau et al. 1997; Whiting et al. 2004). Measures of overall accuracy are affected by the prevalence of the disorder (Leeflang et al. 2009). In addition, estimates may vary greatly between studies due to differences in the criteria used to declare a test positive, patient characteristics, and study design (Leeflang et al. 2013).

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