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This section should discuss the results of the review as well as any limitations of the systematic reviews or research syntheses included in the Umbrella Review and of the review itself (i.e. language, access, timeframe, study design, etc.). The results should be discussed in the context of current literature, practice and policy. Umbrella Reviews are subject to many of the limitations of any systematic review including that potentially relevant studies have been omitted and that some systematic error occurred during the selection, appraisal or data extraction processes. Similarly, Umbrella Reviews are ultimately dependent on the reporting of the included research syntheses which may limit reporting of desirable details of interventions for example in the Umbrella Review report. Inherent bias exists in the reporting of an Umbrella Review as one round of appraisal and extraction, where errors may arise, has already been performed in the conduct of the included systematic review or meta-analysis. Umbrella Reviews will also always be limited by the coverage of existing systematic reviews or research syntheses. For example, if an existing intervention or phenomena of interest is yet to be addressed in a systematic review, an Umbrella Review will never identify it.