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The objectives of meta-analysis should be pre-specified in the review protocol. There are different legitimate objectives for a meta-analysis: to improve statistical power to detect a treatment effect, to estimate a summary average effect, to identify subsets of studies (sub-groups) associated with a beneficial effect, and to explore if there are differences in the size or direction of the treatment effect associated with study-specific variables Los objetivos del metaanálisis deben ser especificados previamente en el protocolo de revisión. Existen diferentes objetivos legítimos para un metaanálisis: mejorar el poder estadístico para detectar un efecto de tratamiento, estimar un efecto promedio resumen, identificar subconjuntos de estudios (subgrupos) asociados con un efecto beneficioso y explorar si existen diferencias en el tamaño o la dirección del efecto del tratamiento asociadas a variables específicas del estudio (Normand 1999).